Abstract
A novel Pd‐catalyzed method for the synthesis of various naphtho[1,2‐b]furans from propargyl carboxylates bearing a furanyl group with organoborons is described. This cascade reaction involves Pd0‐catalyzed allenylation, 6π‐electrocyclization and 1,3‐H migration process. Control experiments suggested the base (Cs2CO3) play an essential role for the hydrogen migration. Wide substrate scope with easily accessible starting materials and good functional group tolerance indicate that this protocol may provide a general approach to construct naphtho[1,2‐b]furan frameworks which are important in natural product synthesis and medicinal chemistry.
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