Abstract
A palladium catalysed, three-component cascade reaction was employed for the regiospecific and stereoselective synthesis of novel substituted (Z)-2-butene 1,4-diamine analogues and substituted 4-aryloxy but-2-enyl amine analogues. Allenes were first synthesised from the corresponding alkynes using the Crabbé reaction and then reacted with a large range of commercially available aryl iodides and amines to generate a library of small molecules. The reaction is compatible with aryl iodides containing both electron-donating and electron-withdrawing groups. Amines of different sizes can also be utilised with no noticeable effect on the yield, regiospecificity or stereoselectivity.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.