Palladium(0)-catalyzed Ring Expansion Reactions of Hydroxy Methoxyallenylisoindolinones via Inter- and Intramolecular Carbopalladation Using Aryl and Vinyl Halides

Abstract

Palladium(0)-catalyzed one-atom ring expansion of various hydroxy methoxyallenylisoindolinones 2 proceeded in the presence of aryl and vinyl halides to give the corresponding isoquinolinediones 3 in various yields. Tandem intramolecular carbopalladation-heterocyclic ring expansion reaction of compound 5 was also achieved to give a tetracyclic compound 6.