Abstract
In 17 patients GC samples were reevaluated for histological characteristics, 14 were MSIH and 3 failed in MSI testing, however IHC stainings for the affected MMR protein were negative in all these patients. Six (35%), 4 (23%) and 7 (41%) GC samples showed intestinal type, diffuse type and mixed type characteristics respectively. In 13 GC samples, the tissue surrounding GC could be evaluated. Intestinal metaplasia was diagnosed in 5 (38%) samples and atrophic gastritis in 2 (15%) samples. Pre-malignant gastric lesions were evenly distributed throughout intestinal, diffuse and mixed type gastric cancer samples (p=0.40). Conclusions: This study demonstrates that GC develops along similar histopathologic pathways as sporadic gastric cancer in LS. Pre-malignant lesions in tissue surrounding GC were evident in >50% of samples. These data support upper GI surveillance endoscopy in LS subjects.
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