Abstract
Giant cell tumor (GCT) of bone is a giant-cell-rich bony lesion associated with abundant multinucleated osteoclast-type giant cells. It is a primary neoplasm of bone with characteristic clinical, radiological, and pathological features. It is an expansive and lytic lesion without periosteal reaction and prominent peripheral sclerosis. Giant cells are also seen in other diseases like giant cell granuloma of the jaws, traumatic bone cyst, aneurysmal bone cyst, and jaw tumor of hyperparathyroidism. We present a unique case of GCT of palate in a 30-year-old female.
Highlights
Giant cell tumor of bone or Osteoclastoma is a benign giant cell tumor characterized by mononuclear cells proliferation intermixed with multinucleated osteoclast-like giant cells
Because of their unpredictable nature, these lesions are no longer termed as “Benign.” The mononuclear cells, considered to be nonneoplastic and reactive in nature, they are seen in distant lung metastases [1]
Various bone tumors reveal multinucleated giant cells which often should be differentiated from Giant cell tumor (GCT)
Summary
Giant cell tumor of bone or Osteoclastoma is a benign giant cell tumor characterized by mononuclear cells proliferation intermixed with multinucleated osteoclast-like giant cells. Because of their unpredictable nature, these lesions are no longer termed as “Benign.” The mononuclear cells, considered to be nonneoplastic and reactive in nature, they are seen in distant lung metastases [1]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
