Abstract
During palate fusion in mammals, the adhesion of opposing medial edge epithelium (MEE), the epithelium covering the tips of palatal shelves, is an essential event whose alteration causes cleft palate (Greene and Pratt, 1977). The initial adhesion of these epithelia seems to be related to the appearance of certain changes in their most superficial cells occuring just prior to the contact between palatal shelves. The most striking change observed is the presence of a coat formed by glycoconjugates, whose experimental removal causes the in vitro inhibition of palatal shelf adhesion
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