Abstract
Experimental rats were given pairings in which placement in a distinctive chamber was followed by an injection of lithium chloride; control rats received unpaired exposures. After two pairings, some of the experimental rats were observed to salivate in the chamber prior to the injection of lithium. The probability of this response increased with further training. No salivary responses were seen in control rats. This pattern of findings indicates that the pairings of a conditioned stimulus, the distinctive chamber, with an unconditioned effect produced by lithium resulted in Pavlovian conditioning of a salivary response. Since lithium was not observed to evoke salivary responding in the absence of conditioning, the conditioned salivary response was probably compensatory to the drug effect.
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