Paired tone facilitation in dorsal cochlear nucleus neurons: A short-term potentiation model testable in vivo

Abstract

It has been suggested that the dorsal cochlear nucleus (DCN) is involved in coding stimulus history or prior auditory activity [Manis (1989) J. Neurophys., 61, 149–161; Manis (1990) J. Neurosci., 10, 2338–2351]. The major output neurons of the DCN are the fusiform (pyramidal) cells which are thought to receive excitatory inputs from the descending branch of the acoustic nerve onto their basal dendrites and significant inhibitory glycinergic and GABAergic inputs to the soma and dendrites. The apical dendrites of these neurons lie within the molecular layer of the DCN and encounter parallel fibers which are thought to utilize the excitatory amino acid neurotransmitter glutamate. In this study of anesthetized chinchillas, we found that, in contrast to the responses of acoustic nerve fibers and most cochlear nucleus neurons which are masked by an appropriate preceding signal, many DCN principal cells are facilitated during the second of two identical stimuli. Facilitated DCN responses often have a reduced interspike interval and a more chopper-like temporal response pattern to the second characteristic frequency tone. This paired tone facilitation in the chinchilla DCN provides an in vivo model of short-term potentiation elicited by sensory stimulation similar to the paired-pulse facilitation observed with electrical stimulation in other models.