PAIN SYNDROM IN CASES OF PATIENTS WITH A COMBINATION OF CHRONIC PANCREATITIS AND HYPERTENSION: RELATIONSHIPS, INTERACTIONS, CORRECTION

Abstract

The aim: To identify the relationships and interactions of the pain development in cases of patients with a combination of Chronic Pancreatits and Arterial Hypertension, with the next correction Materials and methods: We have conducted a comprehensive examination of 102 patients with a diagnosis of Chronic Pancreatitis in combination with stage II Arterial Hypertension during 2018-2020. The investigative contingent was divided by two study groups which depended from the treatment regimen. The first (I) group (n = 53) received basic therapy (BT) in accordance with the requirements of the relevant clinical protocols; the treatment of the second (II) group (n = 49) included the basic therapy with optimization (OT) by mineralocorrection (Zinc, Selenium, which have antioxidant properties), ω-3 polyunsaturated fatty acids and Folic Acid. The therapy duration was 8 weeks. Results: The performed regression analysis was mathematically substantiated the influence of the studied laboratory parameters of the inflammatory response and antioxidant system on the formation, dynamics of abdominal pain (the main clinical sign of CP) and the value of PAP (hypertensive vascular remodeling marker and risk predictor of cardiovascular events). The severity of abdominal pain is significantly influenced by leukocytes, ESR, α1-AT, cortisol, CRP, Bilirubin and Urea, and the value of PAP – CRP and selenium, from laboratory parameters of the inflammatory response and AOS, Conclusions: The effectiveness of the assigned optimized treatment scheme has been proven, which is indicated by the appearance of a reliable regression coefficient on the parameter of glutathione peroxidase after completion of treatment in comparison with patients used basic therapy