Pain reliever combinations in treatment of patients with acute musculoskeletal back pain

Abstract

Objective: to compare the clinical efficacy of complex therapy, including a combination of a nonsteroidal anti-inflammatory drug (NSAID) with a muscle relaxant and B vitamins in acute musculoskeletal back pain (MSBP). Patients and methods. We enrolled 66 patients with acute MSBP, 27 men and 39 women, mean age – 52.8 [29.4; 68.8] years. All patients had different pain localization: 36 (54.5%) – lumbodynia, 22 (33.3%) – cervicodynia, 8 (12.2%) – thoracodynia. Visual analog scale (VAS) was used to assess pain intensity. Patients in the 1 st group (n=32) were prescribed with complex therapy, including Russian drugs meloxicam (Amelotex 15 mg per day), tolperison (Kalmirex), and a neurotropic multivitamin supplement Compligam B. Patients in the 2 nd group (n=34) received a combination of only two of the three drugs. We assessed pain intensity with VAS, disability duration, and treatment effectiveness from the doctor's and patient's perspectives. Results and discussion. After 5 days of treatment, pain regression was noted in both groups; pain reduction by 50% or more from the initial level prevailed in 1 st group (p=0.03). A rapid NSAID dose decrease prevailed in the 1 st group; from the 5 th to the 10 th day, all patients switched to the 7.5 mg meloxicam dose. The duration of temporary disability in the 1 st group was less than 7 days, in the 2 nd group – 9 days (p<0.05). Complex therapy in group 1 was more effective than therapy in group 2, according to doctors and patients (p<0.05). Conclusion . The combination of NSAID with a muscle relaxant and B vitamins can reduce the duration and the incidence of adverse drug reactions of NSAID therapy, and reduce the duration of temporary disability.