Pain Relief and Antimicrobial Activity in Alveolar Osteitis after Platelet-Rich Fibrin Application—A Non-Randomized Controlled Study

Damian Chybicki,Anna Janas-Naze

doi:10.3390/app12031324

Damian Chybicki, Anna Janas-Naze

Open Access

https://doi.org/10.3390/app12031324

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Abstract

The objective was to compare pain relief in alveolar osteitis achieved by the application of platelet-rich fibrin (PRF) and aspirin cones, and to assess the influence of both treatments on bacterial concentrations in post-extraction wounds. A split-mouth, single-center, non-randomized controlled trial was conducted in 30 patients. Pain relief was assessed using the visual analog scale at three time points (before, 24 h after, and 48 h after intervention). Bacterial concentrations were evaluated from cultures of swab samples collected at the three time points. A Wilcoxon matched-pairs signed-rank test was performed to detect differences in distributions of scalar variables between treatment with PRF and aspirin cones. Pain relief at 24 h and 48 h after treatment was significantly higher (p = 0.003) with PRF application than with aspirin cone placement. Additionally, PRF application caused a significantly higher reduction in aerobic bacteria concentration, an average increase, instead of a decrease, in lactic acid bacilli concentration in the first 24 h, and a significantly greater increase in streptococci concentration at 48 h follow-up. PRF provides better pain relief than aspirin cones in alveolar osteitis. Bacterial concentrations in the extraction wounds are consistent with the pain relief achieved after PRF or aspirin application.

Highlights

Alveolar osteitis is an unavoidable complication in clinics because tooth extraction remains one of the most common procedures in oral surgery.a noticeable emphasis is placed on understanding the mechanism behind alveolar osteitis and on searching for new methods of rapid tissue restoration and pain relief [1,2,3].This complication was first described by Crawford in 1896 [2]
We aimed to address this knowledge gap through a non-randomized clinical trial with two objectives: first, to compare pain relief in alveolar osteitis after the application of platelet-rich fibrin (PRF) and aspirin cones, and second, to analyze bacterial concentrations in the extraction wound after the application of each treatment
In the light of the results presented in this paper, we conclude that our initial hypothesis, where the properties of PRF surpass those of acetylsalicylic cones, is confirmed, especially in reference to pain relief after application

Summary

Introduction

A noticeable emphasis is placed on understanding the mechanism behind alveolar osteitis and on searching for new methods of rapid tissue restoration and pain relief [1,2,3] This complication was first described by Crawford in 1896 [2]. Pain is the fundamental and primary symptom of dry sockets; occasionally, the acute and severe nature of the pain can prevent a patient from performing professional and social activities. This neuralgic type of pain can occur anytime between the first and third day after the extraction of permanent teeth and increases with time [1,4]

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