Abstract
Purpose: Untreated meniscal injury is a common trigger for post-traumatic osteoarthritis (PTOA) and ongoing joint pain. The pain phenotype in PTOA can be quite complex and comprises varying levels of nociceptive, inflammatory and neuropathic pain. Females are more susceptible to OA and are more likely to report pain. Whether these sex-specific differences are due to divergent neurophysiological processing of pain is unknown. The aim of this study was to compare the sexes with respect to mechanonociception, pain and joint neuropathy in the medial meniscus transection (MMT) model of PTOA.
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