Pain Management Using Nano-Bio Fusion Gel in Fixed Orthodontic Therapy-Induced Gingivitis: A Split-Mouth Design Study

Mohammad Khursheed Alam,Nafij Bin Jamayet,Srinivas Munisekhar Manay,Ammar A Siddiqui,Kiran Kumar Ganji,Alreshidi Meshari

doi:10.3390/app112311463

Abstract

Nanotechnology-based products containing antioxidants may be effective adjuvants in the treatment of periodontal diseases. To assess the treatment effect of nano bio-fusion gel (NBFG) in pain perception (PP) in fixed orthodontic therapy-induced gingivitis (FOTIG). The gel contains propolis, vitamin C, and vitamin E in the form of nanoemulsion. Thirty-two patients were finally selected from the orthodontic clinic after assessments for FOTIG. Patients were allocated randomly into active and placebo-control groups. Patients were evaluated at three intervals (T1, T2, and T3). Pain perception using a numeric rating scale (NRS) was performed at baseline (T1), on the 7th day (T2) and on the 28th day (T3) on his/her visit to an orthodontic clinic. In the T1, T2, and T3 period, patients apply NBFG (active or placebo side) to their gingiva after brushing two times a day for 28 consecutive days. Results: The baseline data between the active or placebo group showed almost similar PP. From T1 to T2 and T3, the active or placebo-control group showed significant improvement in PP over time. Compared to placebo, the active group showed highly significant (p ≤ 0.001, T1 to T2 and T2 to T3) improvement in PP. The use of NBFG is an effective means of improvement in PP of FOTIG cases.

Highlights

During fixed orthodontic treatment (FOT), 56.8% and 34.4% of gingivitis reported as worldwide morbidity in adolescent and adult group [2]
The results of mean rank score in the active group indicate that the pain perception reduced over time, i.e., from T1 to
nano bio-fusion gel (NBFG) is areduction highly efficient were correlated with increased in PP. nano-bio fusion gel, produced for the first time, with a new technology named nano-bio fusion

Summary

Introduction

After assessing benefits and risks to the patients, the choice of planning the fixed orthodontic treatment (FOT) should be made. Among problems during FOT, almost all of the patients suffer from pain and/or discomfort. The level of PP of the FOT patients varies in different stages [1]. Investigators are always interested in non-invasive and consistent techniques to overcome the chances of pain occurrence due to FOTIG. As an adjunct with routine oral hygiene, scaling and root planing non-invasive practices are applicable to treat gingivitis [4,5]. With meticulous maintenance of oral hygiene, these problems can be minimized. A number of the patients have failed to follow the oral hygiene instructions suitably, which sometimes results in irreparable impairment to the periodontal structures [6]

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Conclusion