Abstract

The opioid epidemic continues to be a significant public health concern. On the surface, it appears difficult to understate the profound consequences and unnecessary loss of life at the hands of the opioid crisis throughout the 2010s. This reality should not dissuade rigorous attention toward those who have suffered unnecessarily due to an overreaching backlash toward the opioid crisis.Oncology patients have been significantly impacted on both ends of the opioid crisis. Like other populations, cancer patients were first affected during the initial surge of opioid availability, prescription, and use at the beginning of the crisis, where opioid abuse and overdose negatively impacted cancer patient populations at similar rates as the general population. Yet, cancer patients were perhaps even more heavily affected during secondary events after the initial crisis, as opioid restrictions and the stigmatization, undoubtedly beneficial in many spaces, of opioid use became prevalent across the American society. During this second period of the opioid crisis (loosely from 2013 to the present day after the Veterans Health Administration Opioid Safety Initiative started), restrictions on opioids have significantly decreased the use and access of opioids for cancer patients.Management of pain, in general, is a complex topic, and cancer pain is no exception. Cancer patients may experience pain related to the disease itself, its treatment, or other comorbidities. This review aims to clarify the impact of reducing opioid use on cancer patients over the past eight years. We summarize the challenges facing providers as they attempt to manage cancer-related pain. Additionally, we propose tools for best practices to reduce the unnecessary suffering of cancer patients and protect against the overuse and abuse of opioids.

Highlights

  • BackgroundThe opioid crisis continues to be a significant public health concern

  • This review aims to clarify the impact of reducing opioid use on cancer patients over the past eight years

  • Opioid-related deaths are more prominent in the general population compared to the cancer patient population [2], there is an increased prevalence of opioid use among cancer patients, and the rate of opioid abuse is approximately similar between the two populations [3,4,5,6]

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Summary

Introduction

The opioid crisis continues to be a significant public health concern. According to the Centers for Disease Control and Prevention (CDC), in 2019, there were nearly 50,000 deaths attributed to opioid overdose in the United States [1]. Initiating opioid treatment for cancer-related pain is an effective intervention resulting in reasonable pain control in 75% of patients. A multidisciplinary approach is beneficial and provides further insight into the obstacles of opioid use and misuse This team includes, but is not limited to, medical and interventional pain specialists, physical and occupational therapy, psychiatrists and psychologists, and palliative care specialists. 3. Screener and Opioid Assessment for Patients with Pain-Revised is a 24-question tool used to predict drug misuse before initiation of long-term opioid therapy but has lower sensitivity than other tools [33,39,40,41,42]. Cancer patients who receive long-term opioid therapy are at risk of developing tolerance, dependence, and NMOU; they need opioid maintenance therapy.

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14. McDonald J
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