Abstract

IntroductionAs a typical consequence of bleeding into muscles and joints, patients with severe hemophilia suffer from acute and chronic pain. In spite of its high prevalence, pain in this patient group is not always sufficiently considered or treated in an effective manner.AimThe recommendations presented in this paper address possible improvements in pain management in hemophilia patients and particularities that have to be taken into account in this patient group.MethodThe manifold aspects of pain management in hemophilia patients were discussed within the framework of an expert meeting. Based on the available literature and the experts’ clinical experience, the participants developed a set of recommendations presented in this paper.ResultsPain management in patients with hemophilia is often insufficient, a fact that not only influences the patients’ quality of life but also implies the risk of difficult to manage chronic pain. Both the prevalent polypharmacy (due to comorbidities) as well as the underlying disease itself present special challenges to pain therapy in this patient group. The present review and recommendations are intended to support medical professionals in recognising the risks of pain chronicity, applying basic principles of multimodal pain therapy, including the options of psychological intervention and modalities of physical medicine in therapy concepts, and reaching a comprehensive understanding of the range of analgesic options available.

Highlights

  • Background and goalNowadays, life expectancy in patients with hemophilia A or B is similar to healthy populations, provided the appropriate therapy is available; severe forms of this coagulation disorder with acute and chronic pain due to bleeds in joints and tissue structures pose a significant problem

  • An interdisciplinary group of experts has developed recommendations for pain therapy in hemophilia patients which we present in this paper

  • Because of its effect on coagulation, acetylsalicylic acid is contraindicated for the treatment of hemophilia patients

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Summary

Results

Pain management in patients with hemophilia is often insufficient, a fact that influences the patients’ quality of life and implies the risk of difficult to manage chronic pain. Both the prevalent polypharmacy (due to comorbidities) as well as the underlying disease itself present special challenges to pain therapy in this patient group. C. Ay Clinical Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna/Vienna General Hospital, Vienna, Austria. Wagner University Department of Physical Medicine, Rehabilitation and Occupational Medicine, Medical University of Vienna/Vienna General Hospital, Vienna, Austria. Thom University Department of Paediatric and Adolescent Medicine, Medical University of Vienna/Vienna General Hospital, Vienna, Austria.

Background and goal
Summary of selected analgesics interactions
Summary of recommendations
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