Abstract
BackgroundAs it is less known about the prevalence and characteristics of pain in the patients with interstitial lung disease (ILD), this paper aims at determining the characteristics of the pain in the patients with ILD.MethodsSubjects with ILD and health controls with the matched ages and genders completed Short Form McGill Pain Questionnaire (SF-MPQ) and part of the Brief Pain Inventory (BPI) Short Form to elicit the characteristics of the pain. The patients with ILD were also assessed through Pulmonary Function Test, Six Minutes Walking Test (6MWT), modified Medical Research Council Dyspnea Scale (mMRC) for state of the illness and measured health-related quality of life (HRQoL) by Short Form-36 (SF-36) and psychological associations by Hospital Anxiety and Depression Scale (HADS).ResultsA total of 63 subjects with ILD and 63 healthy controls (HC) were recruited in our study. The prevalence of the pain was 61.9% in ILD versus 25.3% in HC (P = 0.005) and the median score of the pain rank index (PRI) in ILD was higher than that in HC (P = 0.014). Chest (46.1%) accounted for the highest of overall pain locations in subjects with ILD. Associated clinical factors for pain intensity in the patients with ILD included exposure history of risk factors of ILD, with a longer distance of 6MWD (≥ 250 m), and a higher mMRC score (2–4). The patients with ILD and pain are more likely to suffer impaired HRQoL (P = 0.0014) and psychological problems (P = 0.0017, P = 0.044).ConclusionThe pain is common in those with ILD and the pain intensity is associated with exposure history, 6MWD, and mMRC score. The patients with ILD and pain were possibly to suffer depression, anxiety, and impaired HRQoL.
Highlights
Interstitial lung diseases (ILDs) refer to a complex and large group of diseases that are typically characterized by the basic pathological changes of diffuse lung parenchyma, alveolar inflammation, and interstitial fibrosis with substantial morbidity and mortality [1, 2], whichShen et al Respir Res (2020) 21:297In 2020, the current International Association for the Study of Pain (IASP) defined pain as “An unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damages” [9]
The objectives of this study were to determine the characteristics of pain in patients with ILD compared with healthy, age and gender-matched control participants, the patients with ILD complicated with other respiratory disease and explore the association between pain, dyspnea, physiology function, psychological symptoms and quality of life
According to Short Form McGill Pain Questionnaire (SF-MPQ), the prevalence of pain was 39 (61.9%) in ILD Group versus 16 (25.3%) in HealthControl Group (p = 0.005) and the median score of pain rank index (PRI) was 2.5 (IQR 1.0–5.0) in ILD versus 2.0 (IQR,1.0–2.0) in healthy controls (HC) (P = 0.014)
Summary
Interstitial lung diseases (ILDs) refer to a complex and large group of diseases that are typically characterized by the basic pathological changes of diffuse lung parenchyma, alveolar inflammation, and interstitial fibrosis with substantial morbidity and mortality [1, 2], whichShen et al Respir Res (2020) 21:297In 2020, the current International Association for the Study of Pain (IASP) defined pain as “An unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damages” [9]. The objectives of this study were to determine the characteristics of pain (prevalence, intensity, location, and pain sensory) in patients with ILD compared with healthy, age and gender-matched control participants, the patients with ILD complicated with other respiratory disease and explore the association between pain, dyspnea, physiology function, psychological symptoms and quality of life. As it is less known about the prevalence and characteristics of pain in the patients with interstitial lung disease (ILD), this paper aims at determining the characteristics of the pain in the patients with ILD
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