Pain Increases the Risk for Sarcopenia in Community-Dwelling Adults: Results From the English Longitudinal Study ofAgeing.

Abstract

Pain and sarcopenia are common in older people. Cross-sectional studies have reported a significant association between these two conditions, but cohort studies exploring pain as a potential risk factor for sarcopenia are scarce. Given this background, the aim of the present work was to investigate the association between pain (and its severity) at baseline, and the incidence of sarcopenia over 10years of follow-up in a large representative sample of the English older adult population. Pain was diagnosed using self-reported information and categorized as mild to severe pain at four sites (low back, hip, knee, and feet). Incident sarcopenia was defined as having low handgrip strength and low skeletal muscle mass during the follow-up period. The association between pain at baseline and incident sarcopenia was assessed using an adjusted logistic regression analysis, and reported as odds ratios (ORs) with their 95% confidence intervals (CIs). The 4102 participants without sarcopenia at baseline had a mean ± standard deviation age of 69.7±7.2years, and they were mainly male (55.6%). Pain was present in 35.3% of the sample. Over 10years of follow-up, 13.9% of the participants developed sarcopenia. After adjusting for 12 potential confounders, people with pain reported a significantly higher risk of sarcopenia (OR=1.46: 95% CI: 1.18-1.82). However, only severe pain was significantly associated with incident sarcopenia, without significant differences across the four sites assessed. The presence of pain, particularly severe pain, was associated with a significantly higher risk of incident sarcopenia.