Abstract
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting the motor neurons. It leads to progressive limb weakness, dysphagia, dysarthria, and respiratory failure. Although ALS is described as a disease of “painless weakness,” more recent literature has revealed that pain is a prevalent part of the disease. Commonly, patients may report pain associated with ALS that can be described as either nociceptive, neuropathic, or spasticity/cramping. A thorough pain assessment in patients with ALS should always be undertaken. While evidence to support their use is largely lacking, anecdotal reports support several nonpharmacologic and pharmacologic treatment options that may be offered.
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