Abstract
Pagetoid reticulosis (PR) is a rare type of mycosis fungoides. Clinical symptoms of PR can mimic other skin diseases of papulosquamous, neoplastic, and infectious origin that hampers PR diagnostics. The main histopathologic feature of PR is dense intraepidermal infiltration by medium to large-size lymphocytes through the epidermis leading to pagetoid plaque formation. There are three common immunophenotypes of PR: CD4-positive T-helper phenotype (CD3+, CD4+, CD8); T-cytotoxic/suppressor (CD3+, CD4, CD8+); and double negative phenotype (CD3+, CD4, CD8). The clinical case of PR with rare immunophenotype (CD2+, CD3+, CD8+ lymphoid infiltrate) is presented. The careful analysis of the symptoms, pathomorphological and immunohistochemical data is necessary for accurate PR diagnostics.
Highlights
Pagetoid reticulosis (PR) is a rare type of mycosis fungoides
The main histopathologic feature of PR is dense intraepidermal infiltration by medium to large-size lymphocytes through the epidermis leading to pagetoid plaque formation
The careful analysis of the symptoms, pathomorphological and immunohistochemical data is necessary for accurate PR diagnostics
Summary
Pagetoid reticulosis (PR) is a rare type of mycosis fungoides. For citation: Sergeeva EYu, Khorzhevskii VA, Ruksha TG. Актуальность Педжетоидный ретикулез (ПР), или болезнь Ворингера — Колоппа является одним из редких видов грибовидного микоза (ГМ) — первичной Т-клеточной кожной неходжкинской лимфомы.
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