Abstract
Pagetoid dyskeratosis is a benign incidental pathologic finding that has been reported in many distinct skin lesions on various locations of the body. A man who had pagetoid dyskeratosis within lesions of the penile shaft is described and similar cases of pagetoid dyskeratosis in lesions of the male genitalia are reviewed. The patient was a 26-year-old healthy man who developed several asymptomatic penile papules that were refractory to topical imiquimod 5% cream and cryotherapy. Snip biopsies were performed and microscopic examination revealed pagetoid dyskeratosis. PubMed was searched for the following terms: cell, clear, dyskeratosis, genitalia, pagetoid, penile, penis, prepuce, scrotum, and shaft. The papers containing these terms and their references were reviewed. Pagetoid dyskeratosis has been observed in lesions on the prepuce and scrotum; this case report now expands the distribution of this finding to the penile shaft. Clinicians and pathologists should be aware of this intriguing potential incidental finding within skin lesions of the male genitalia.
Highlights
Pagetoid dyskeratosis is a benign incidental pathologic feature
Pagetoid dyskeratosis is a benign incidental pathologic finding that has been reported in many distinct skin lesions on various locations of the body
PubMed was searched for the following terms: cell, clear, dyskeratosis, genitalia, pagetoid, penile, penis, prepuce, scrotum, and shaft
Summary
Pagetoid dyskeratosis is a benign incidental pathologic feature. It has been observed in several skin lesions [1]. Distant A) and closer B) views with markings and distant C) view without markings show the clinical features of pagetoid dyskeratosis that presented as proximal (arrow), middle (asterisk), and distal (circle) asymptomatic, flesh-colored papules on the proximal dorsal penile shaft of a 26-year-old man. There were multiple large, round intraepidermal pale cells presenting singly and in clusters (Figure 2) The cells resembled those seen in extramammary Paget’s disease, containing condensed pyknotic nuclei with perinuclear halos of clear cytoplasm. Pathology features of pagetoid dyskeratosis are present in the asymptomatic, flesh-colored papule at the base of the dorsal penile shaft of a 26-year-old man. Immunoperoxidase staining with p16 was negative within the lesional keratinocytes of all three lesions, making a human papillomavirus infection unlikely Pathology features of another asymptomatic, flesh-colored papule on the proximal dorsal penile shaft of a 26-year-old man demonstrate pagetoid dyskeratosis. There has been no recurrence or new lesions in the subsequent six months
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