Paeoniflorin Inhibits the Proliferation and Metastasis of Ulcerative Colitis-Associated Colon Cancer by Targeting EGFL7.

Abstract

In this study, we studied the therapeutic potential of PF in mouse models of CAC. PF could inhibit the proliferation, migration, invasion, and clone formation and promote the apoptosis of colon cancer cells. Furthermore, PF showed a good effect on inhibiting the aggregation and infiltration of inflammatory cells, protecting the intestinal mucosal barrier, and inhibiting the growth of colon tumors in the AOM/DSS-induced CAC model. PF also significantly inhibited the expression of TNF-α, IL-1β, IL-6, IL-13, and CEA-related inflammatory factors in the AOM/DSS-induced CAC model by inhibiting the TLR4/NF-κB signaling pathway and EGFL7 expression. Therefore, PF showed a potential therapeutic effect on mice in the CAC model by inhibitingTLR4/NF-κB mediated inflammatory response and EGFL7 expression.