Paeo‐tang attenuates disharmony between the heart and kidney in L‐NAME‐induced hypertension

Abstract

Hypertension has been approved to cause disharmony between the heart and kidney such as cardiac hypertrophy and kidney dysfunction. In traditional oriental medicine Paeo‐tang (PET) has been shown to have effects on blood circulation improvement. However, the beneficial effect of PET on hypertension remains unknown. In this study, we investigated that PET attenuates blood pressure and suppresses cardiac hypertrophy in NG‐nitro‐L‐arginine methylester (L‐NAME) rat model. Hypertensive rat models were induced by the administration of L‐NAME (40 mg/kg/day) and then PET (50 or 100 mg/kg/day) or Olmetec was treated for 2 weeks. PET treatment significantly suppressed the systolic blood pressure and decreased intima‐media thickness in the thoracic aorta. PET restored the L‐NAME‐induced decrease in aortic relaxation response to acetylcholine and atrial natriuretic peptide (ANP). However, PET didn't restore the aortic relaxation response to sodium nitroprusside. PET markedly restored the phosphorylation of endothelial nitric oxide synthase in aortic tissue. Heart weight and ANP mRNA expression in heart tissue were decreased by PET in a dose‐dependent manner. PET ameliorated the functional decline in the kidney such as albumin, blood urea nitrogen, creatinine. These results demonstrated that PET possesses vascular protective effects against L‐NAME‐induced hypertension. In addition, PET regulates harmony between the heart and kidney via inhibition of cardiac hypertrophy and renal dysfunction.Support or Funding InformationThis abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.