Abstract
Globally, retinoblastoma is the most common primary intraocular malignancy occurring in children. This paper documents the recent incidence rates of retinoblastoma by age and sex groups from the Population Based Cancer Registries (PBCRs) of Bangalore, Mumbai, Chennai, Delhi and Kolkata using the data from the National Cancer Registry Programme. Relative proportions, sex ratio, method of diagnosis, and incidence rates (crude and age standardized) for each PBCR and pooled rates of the five PBCRs were calculated for the years 2005/06 to 2009/10. Standard errors and 95% confidence limits of ASIRs by sex group in each PBCR were calculated using the Poisson distribution. Standardised rate ratios of ASIR by sex group and rate ratios at risk were also calculated. The maximum retinoblastoma cases were in the 0-4 age group, accounting for 78% (females) and 81% (males) of pooled cases from five PBCRs. The pooled crude incidence rate in the 0-14 age group was 3.5 and the pooled ASIR was 4.4 per million. The pooled ASIR in the 0-4, 5-9 and 10-14 age group were 9.6, 2.0 and 0.1 respectively. The M/F ratio in Chennai (1.9) and Bangalore PBCRs (2.0) was much higher than the other PBCRs. Among the PBCRs, the highest incidence rate in 0-4 age group was found in males in Chennai (21.7 per million), and females in Kolkata (18.9 per million). There was a distinct variation in incidence rates in the PBCRs in different geographic regions of India.
Highlights
Retinoblastoma is the most common primary intraocular malignancy occurring in children
Among the Population Based Cancer Registries (PBCRs), the highest incidence rate in 0-4 age group was found in males in Chennai (21.7 per million), and females in Kolkata (18.9 per million)
Childhood cancers in age group 0-14 years ranged from 0.5 % to 5.8 % of all cancers in the PBCRs in India (National Cancer Registry Programme,2012)
Summary
Retinoblastoma is the most common primary intraocular malignancy occurring in children. The incidence of retinoblastoma reported in the Cancer Incidence in Five continents Volume X is lower in the developed nations as compared to the developing countries, and the age standardized incidence rates (ASIR) ranges from 1 per 1,000,000 population in 0 -14 years male and female children in many parts of the world to 8 per 1,000,000 in Blantyre, Malawi in Africa (Forman et al.,2013). Retinoblastoma is a rare disease, and calculation of incidence rates requires reliable data from a defined population at risk. Using the data from the National Cancer Registry Programme (NCRP), India this paper explains the recent incidence rates of retinoblastoma by age and sex groups from the Population Based Cancer Registries (PBCRs) of Bangalore, Mumbai, Chennai, Delhi and Kolkata. This paper documents the recent incidence rates of retinoblastoma by age and sex groups from the Population Based Cancer Registries (PBCRs) of Bangalore, Mumbai, Chennai, Delhi and Kolkata using the data from the National Cancer Registry Programme.
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