Abstract
Condensed polyhedral oligomeric silsesquioxane (POSS) family of materials are very attractive as a nanoscale drug delivery system in cancer therapy. This work describes a novel method for conjugation of poorly soluble anticancer drug paclitaxel (PTX) to octa-aminopropyl polyhedral oligomeric silsesquioxane hydrochloride salt nanoparticles (OA-POSS NPs). The synthesized nanoconjugate of PTX and OA-POSS NPs (PTXn-OA-POSS8-n prodrug) was fully soluble in aqueous solution as compared to the free PTX.
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