Abstract
A considerable interest in cancer research is represented by the development of magnetic nanoparticles based on biofunctionalized polymers for controlled-release systems of hydrophobic chemotherapeutic drugs targeted only to the tumor sites, without affecting normal cells. The objective of the paper is to present the synthesis and in vitro evaluation of the nanocomposites that include a magnetic core able to direct the systems to the target, a polymeric surface shell that provides stabilization and multi-functionality, a chemotherapeutic agent, Paclitaxel (PTX), and a biotin tumor recognition layer. To our best knowledge, there are no studies concerning development of magnetic nanoparticles obtained by partial oxidation, based on biotinylated N-palmitoyl chitosan loaded with PTX. The structure, external morphology, size distribution, colloidal and magnetic properties analyses confirmed the formation of well-defined crystalline magnetite conjugates, with broad distribution, relatively high saturation magnetization and irregular shape. Even if the ability of the nanoparticles to release the drug in 72 h was demonstrated, further complex in vitro and in vivo studies will be performed in order to validate the magnetic nanoparticles as PTX delivery system.
Highlights
A considerable interest in cancer research is represented by development of magnetic nanoparticles based on biofunctionalized polymers for controlled release systems of hydrophobic chemotherapeutic drugs (i.e., Paclitaxel) that can be targeted only to the tumour sites, without affecting normal cells [1,2]
The objective of this paper is to present the synthesis, characterization and preliminary drug delivery evaluation of PTX loaded magnetic nanoparticles based on biotinylated N-palmitoyl chitosan
There are no studies concerning development of magnetic nanoparticles obtained by partial oxidation method, based on biotinylated N-palmitoyl chitosan loaded with PTX
Summary
A considerable interest in cancer research is represented by development of magnetic nanoparticles based on biofunctionalized polymers for controlled release systems of hydrophobic chemotherapeutic drugs (i.e., Paclitaxel) that can be targeted only to the tumour sites, without affecting normal cells [1,2]. Chitosan stands out as a successful polysaccharide endowed with advantageous features, widely involved in the design of magnetic drug-delivery nanosystems with promising results [6,7] These nanosystems need to be functionalized in order to selectively target the cancer cells. A recent review paper highlighted the importance of chitosan-functionalized nanocarriers on enhancing the bioavailability of taxanes (Paclitaxel and Docetaxel) at targeted tumour site [12]
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