Abstract
Packing and molecular interactions of the high resolution crystal structures of tRNAAsp and tRNAPhe are analysed. The close intermolecular contacts are essentially hydrophobic with a mixture of hydrogen bonds and Van der Waals interactions. Two strong stacking interactions are formed in each of the three different crystal packing examined. Except for the specific anticodon-anticodon association observed in tRNAAsp crystal structure, the hydrogen bonds formed have no sequence specificity and most of them involve 02' backbone atoms. Many contact area involve part of the molecules with relatively high temperature factors. Molecular interaction in crystal packings offer another good opportunity to analyse the correlation between conformational flexibility and molecular recognition.
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