Abstract
Using standardized chromatographic conditions with respect to carbon dioxide and methanol containing 1% of triethylamine as modifier, the chromatographic behaviour of omeprazole and four of its analogues was investigated on six types of chromatographic support at 40°C. Superior selectivity was obtained for omeprazole versus its anlogues with NH 2-modified silica and also good peak symmetry (LiChrosorb and Kromasil). Using the present chromatographic system it is possible to detect and separate the analogues added to omeprazole in the 0.5% (w/w) range within 10 min.
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