Pacing and the Non-Invasive Evaluation of Myocardial Fatty Acid Metabolism by Means of 17-123I-Heptadecanoic Acid Scintigraphy

Abstract

The extent of myocardial non-esterified fatty acid (NEFA) oxidation depends among other things on exogeneous NEFA supply and energy demand. In 6 patients with a multi-programmable pacemaker scintigraphy with 17-123Iodo-heptadecanoic acid (17-123I-HDA) was performed to investigate NEFA metabolism at two levels: at a control level (basal heart rate 69 +/- 6) and at increased pace frequency (104 +/- 5). In both situations the derived time-activity curves, measured during a period of 75 min, were fitted with a monoexponential plus a constant curve: A(t) = A(0).exp (-t In2/T1/2) + C. The half-time value, the uptake measured as the peak activity and the relative size of the oxidation pool were determined. The median of the half-time value did not change: 24 min (range 19-31) in the control heart rate study and 22 min (19-27) during the increased pace frequency study. The median of the uptake increased significantly from 33 cpm/pixel/2 mCi/100 kg (23-34) to 40 cpm/pixel/2 mCi/100 kg (35-42; p less than 0.05 Wilcoxon). The median of the relative size of the oxidation pool increased from 57% (52-62) to 69% (63-71; p less than 0.05). We conclude that during pacing the augmented need for NEFA resulted in a demonstrable increase in uptake and oxidation of 17-123I-HDA. This result suggests that radioiodinated NEFA may be a valuable tool to quantify noninvasively the level of the myocardial NEFA metabolism in the human heart.