Pachygyria with cerebellar hypoplasia and tigroid pattern of the white matter secondary to neuronal migration disorders

Abstract

Introduction: Pachygyria is a subtype of the lissencephaly spectrum that is secondary to neuronal migration disorders during embryogenesis, it may be associated with other extracortical anomalies such as cerebellar hypoplasia. Lissencephaly with cerebellar hypoplasia is a very rare malformation. In this form we can also observe a tigroid pattern of the white matter. Case Report: We report a very rare case of an infant with pachygyria with cerebellar hypoplasia and a tigroid appearance of the substance secondary to a neuronal migration disorder. Conclusion: Lissencephaly with hypoplasia of the cerebellum is a very rare malformation. The tigroid pattern of the white matter can be observed in neuronal migration disorders. Magnetic resonance imaging (MRI) of the brain is the key examination in the exploration of lissencephaly.