Abstract

A pair of novel scalemic meroterpenoid dimers, (+)- and (−)-pabmaragramin (1), featuring an unprecedented 6/6/5/6/6/6/5 seven-membered ring system, were obtained from Marasmius graminum via precursor-assisted biosynthesis (PAB). Their structures and absolute configurations were determined on the basis of extensive spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism (ECD) calculations. A plausible biosynthetic pathway for 1 was proposed. Additionally, (+)-1 and (−)-1 exhibited inhibitory activity against α-glucosidase with IC50 values of 3.4 μM and 12.0 μM, respectively.

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