Abstract
found. Among these, two females no-responders to im vitamin K, one with deficiency of XI factor, another with lupus anticoagulant antibodies, were found. All children but the three previously described, improved after im vitamin K administration. Conclusions: The results of our study, performed in a large series of coeliac children and adolescents, demonstrate a prevalence of prolonged INR and prolonged PTT of 6% and 7%, respectively. However, no patient showed any clinical signs of altered coagulation. Coagulation disorders should be related to malabsorption, as suggested by improvement after intramuscular vitamin K administration. This study suggests that there is need for coagulation disorders screening among patients with coeliac disease before performing the intestinal biopsies, in order to correct vitamin K impairment and exclude deficit of specific coagulation factors.
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