Abstract
Methods The examination included 50 formula-fed infants with AD aged 6-12 months old. The main group (n = 30) comprised infants, who received the goat milk-based formula with prebiotics. The reference group (n = 20) – infants, who received a formula based on soy protein isolates. All the patients received standard therapy for AD (antihistamine drugs, local anti-inflammatory therapy, therapeutic and cosmetic skin care, etc.) that did not differ in both groups. The effectiveness of the administered therapy was assessed on the basis of the dynamics of clinical symptoms of disease according to SCORAD score, and also by decrease of total IgE level in serum. The level of total IgE was measured by immune-enzymometric method using the spectrophotometer “Sunrise” (Belgium).
Highlights
Atopic dermatitis (AD) in most of infants is associated with food allergy; cow milk proteins are a main antigen in 80-90% cases
In the main group, the clinical effectiveness of the formula with prebiotics based on New Zealand goat milk amounted to 76.7%, in the reference group – 40%
The analysis of results of immunologic evaluation revealed that initial level of serum total IgE was increased in 82% patients of the main group, mean level was 260 IU/ml
Summary
Atopic dermatitis (AD) in most of infants is associated with food allergy; cow milk proteins are a main antigen in 80-90% cases. The aim of study is examination of the clinical effectiveness of the goat milk-based formula with prebiotics in infants with AD aged 6-12 months old
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