P-94: The effect of Body Mass Index on IVF outcome

Abstract

ObjectiveThe objective of this study was to evaluate the effect of Body Mass Index (BMI) on In Vitro Fertilization (IVF) outcomes.DesignThis was a retrospective analysis of patients undergoing routine IVF. Patients were grouped into 5 categories based on BMI: <21 (group 1), 21-25 (group 2), 26-30 (group 3), 30-35 (group 4), and >36 (group 5). None of the patients were diagnosed as having polycystic ovarian stimulation syndrome. All patients were less than 36 years of age at stimulation start. To control for possible confounding of embryo quality at transfer and BMI grouping, sub-analyses were performed that included only patients that received two “top quality” embryos at transfer.Materials and methodsAll patients underwent ovarian stimulation with injectible gonadotropins and received hCG to induce final follicle maturation. A transvaginal oocyte retrieval was performed 36 hr post hCG injection. Fertilization was achieved either by insemination or ICSI and embryo transfer was performed on days 3, 4 or 5 post oocyte retrieval. At the time of transfer, Day 3 embryos were evaluated and assigned a quality score based on morphological characteristics (number of cells, blastomere multinucleation, degree of fragmentation, and blastomere symetry). Day 4 embryos were scored based on degree of compaction and symetry of compaction. Day 5 embryos were scored based degree of blastocoel formation, integrity of the inner cell mass and integrity of the trophoblast. Clinical pregnancy was defined as an intrauterine gestation sac with documentation of fetal heart beat.ResultsView Large Image Figure ViewerDownload (PPT)ConclusionIncreasing BMI values appear to have a negative impact on pregnancy outcome for IVF. ObjectiveThe objective of this study was to evaluate the effect of Body Mass Index (BMI) on In Vitro Fertilization (IVF) outcomes. The objective of this study was to evaluate the effect of Body Mass Index (BMI) on In Vitro Fertilization (IVF) outcomes. DesignThis was a retrospective analysis of patients undergoing routine IVF. Patients were grouped into 5 categories based on BMI: <21 (group 1), 21-25 (group 2), 26-30 (group 3), 30-35 (group 4), and >36 (group 5). None of the patients were diagnosed as having polycystic ovarian stimulation syndrome. All patients were less than 36 years of age at stimulation start. To control for possible confounding of embryo quality at transfer and BMI grouping, sub-analyses were performed that included only patients that received two “top quality” embryos at transfer. This was a retrospective analysis of patients undergoing routine IVF. Patients were grouped into 5 categories based on BMI: <21 (group 1), 21-25 (group 2), 26-30 (group 3), 30-35 (group 4), and >36 (group 5). None of the patients were diagnosed as having polycystic ovarian stimulation syndrome. All patients were less than 36 years of age at stimulation start. To control for possible confounding of embryo quality at transfer and BMI grouping, sub-analyses were performed that included only patients that received two “top quality” embryos at transfer. Materials and methodsAll patients underwent ovarian stimulation with injectible gonadotropins and received hCG to induce final follicle maturation. A transvaginal oocyte retrieval was performed 36 hr post hCG injection. Fertilization was achieved either by insemination or ICSI and embryo transfer was performed on days 3, 4 or 5 post oocyte retrieval. At the time of transfer, Day 3 embryos were evaluated and assigned a quality score based on morphological characteristics (number of cells, blastomere multinucleation, degree of fragmentation, and blastomere symetry). Day 4 embryos were scored based on degree of compaction and symetry of compaction. Day 5 embryos were scored based degree of blastocoel formation, integrity of the inner cell mass and integrity of the trophoblast. Clinical pregnancy was defined as an intrauterine gestation sac with documentation of fetal heart beat. All patients underwent ovarian stimulation with injectible gonadotropins and received hCG to induce final follicle maturation. A transvaginal oocyte retrieval was performed 36 hr post hCG injection. Fertilization was achieved either by insemination or ICSI and embryo transfer was performed on days 3, 4 or 5 post oocyte retrieval. At the time of transfer, Day 3 embryos were evaluated and assigned a quality score based on morphological characteristics (number of cells, blastomere multinucleation, degree of fragmentation, and blastomere symetry). Day 4 embryos were scored based on degree of compaction and symetry of compaction. Day 5 embryos were scored based degree of blastocoel formation, integrity of the inner cell mass and integrity of the trophoblast. Clinical pregnancy was defined as an intrauterine gestation sac with documentation of fetal heart beat. Results ConclusionIncreasing BMI values appear to have a negative impact on pregnancy outcome for IVF. Increasing BMI values appear to have a negative impact on pregnancy outcome for IVF.