Abstract
Background: Enterocyte apoptosis in necrotizing enterocolitis and other intestinal inflammatory diseases is due in part to nitric oxide over production, and the elaboration of toxic nitrogen intermediates, such as peroxynitrite (PN). We have previously demonstrated that PN-induced apoptosis is associated with Src kinase as well as p38-dependent signaling in enterocytes. Src activates AKT which promotes cell survival. In contrast, p38 activates the transcription factor ATF-2, which up-regulates expression of AKT inhibitory proteins such as PTEN.
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