P925 RECIPIENTS WITH NASH HAVE HIGHER PREVALENCE AND MORE SEVERE CORONARY ARTERY DISEASE COMPARED TO HCV-INFECTED PATIENTS

Abstract

Background and Aims: The evaluation of potential liver donors for transplantation is based in the careful analysis of the clinical, biochemical and histological data. In our center, liver biopsy is performed systematically to minimize the risk of the recipient to receive a suboptimal organ. The aim is to evaluate the main histological findings responsible for the exclusion of livers that were previously selected. Methods: Retrospective study of histological findings in livers for transplantation excluded based on histological criteria. Demographics, laboratory data and the cause of death were collected. Results:We excluded 110 organs from donors, mean age of 46 years, mostly male (59%). Fatty liver disease was the major cause of exclusion, presented as isolated macrovesicular steatosis in 59 patients and steatohepatitis in 5. The Body Mass Index (BMI) was a poor marker for the presence of steatosis since 80% of patients excluded for this had BMI below 25 kg/m. Fibrosis was identified in 22 patients, of which 3 had cirrhosis. Degenerative processes associated with ischemia time excluded 10 livers. Lesions consistent with chronic hepatitis were found in 5 cases. The least common causes were the presence of hepatic granulomas (4patients), hydatid cysts (two cases) and one case of autoimmune hepatitis. Transaminases and cholestasis enzymes did not correlate with histological findings. Conclusions: Liver biopsy before transplantation represents an important complementary test for the success of liver transplantation. The realization of biopsy enables the exclusion of histological changes in patients considered potential donors, thereby decreasing the risk of early and late organ failure. P925 RECIPIENTS WITH NASH HAVE HIGHER PREVALENCE AND MORE SEVERE CORONARY ARTERY DISEASE COMPARED TO HCV-INFECTED PATIENTS S.K. Satapathy, A.C. Flowers, J.M. Vanatta, N. Dbouk, S.P. Nair, J. Eason. Methodist University Hospital, University of Tennessee Health Sciences Center, Internal Medicine, Methodist University Hospital, University of Tennessee Health Sciences Center, Memphis, TN, United States E-mail: aflowe11@uthsc.edu