Abstract

BackgroundThe aim of the study was to examine some endokrinological aspects of intrauterine growth retardation and, in particular, test whether low levels of GH and IGF‐1 in maternal serum are associated with direct evidence of placental dysfunction.MethodProspectively 48 singleton pregnancies with a SGA fetus and 28 with an AGA fetus were examined with maternal serum GH, IGF‐1, IGFBP‐1 and 3, and fetal weight and umbilical artery pulsatility index at 33 weeks of gestation.ResultsSerum IGF‐1 was lower in the SGA group, which was accounted for in the subgroup of SGA with increased pulsatility index.ConclusionA decreased maternal level of IGF‐1 seems to be specifically related to placental dysfunction as diagnosed by increased Doppler flow pulsatility

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