P895 Relationship between left ventricular function components and cardiovascular risk factors in asymptomatic individuals

Abstract

Abstract Funding Acknowledgements none Background and Aim Coronary artery disease is commonly related to conventional cardiovascular (CV) risk factors. The exact role of those risk factors in early development of CV disease or left ventricular (LV) dysfunction before the development of sign and symptoms remains debated. We studied the relationship between conventional risk factors and LV systolic, diastolic and synchronous function in a population sample of asymptomatic individuals. Methods All participants underwent a detailed echocardiographic examination as part of a cross-sectional survey for the prevalence of coronary risk factors in randomly selected individuals from general population. LV end-systolic and end-diastolic dimensions, and LV volumes and ejection fraction (EF) were all calculated. From the spectral Doppler flow, LV early diastolic (E wave) and atrial systolic (A wave) velocities were measured and E/A ratio calculated. LV filling time (FT) was also measured from the onset of E wave to the end of A wave, and LV ejection time (ET) from the onset to the end of aortic Doppler velocity. Global LV dyssynchrony was assessed using total isovolumic time (T-IVT) as 60 – (total filling time + total ejection time), and Tei index was also calculated. Results The study population comprised 184 individuals (96 male and 88 female, mean age 55.9 (11.3), range 25-78 years). There was no relationship between systolic LV function expressed by EF and CV risk factors. Markers of diastolic function: LV filling velocities and E/A ratio, were correlated with age (r= -0.36, p < 0.000, r= -0.57, p < 0.000, respectively), with glycemia (r= -0.21, p < 0.000, r= -0.14, p = 0.004,) and with systolic blood pressure (r= -0.31, p < 0.000, r= -0.34, p < 0.000). Markers of LV dyssynchrony, in the form of prolonged T-IVT, and raised Tei index, directly correlated with age, glycemia and systolic blood pressure (r = 0.58, p < 0.000, r = 0.18, p < 0.000, r = 0.33, p < 0.000, respectively). However, when these correlations were adjusted for age in a multivariate analysis, the statistical significance was strongly reduced (LV filling) or completely lost (IVT and E/A). Conclusions In normal asymptomatic population, age, rather than CV risk factors, is the main determinant of changes in diastolic and synchronous function.