P89. Biochemical parameters of the first trimester in preeclampsia

Abstract

Introduction Preeclampsia is a multisystem disorder with complex and incompletely understood etiopathogenesis. Objective The aim of this study is to determine is there a statistically significant difference in the values of biochemical markers in serum of pregnant women between 11 and 14 weeks of gestation, between pregnant women with preeclampsia and the control group of pregnant women with physiological pregnancy. Methods This research is conducted as a prospective study in the period 2013–2014 at the Department of Obstetrics and Gynecology and the Center for Laboratory Medicine, Clinical Center of Vojvodina. The study included a total of 183 pregnant women who were outpatients between 11 and 14 weeks of gestation, because of screening for fetal and chromosomal abnormalities of the fetus. The women were followed until the end of pregnancy when they were divided into study group ( n =72) who developed preeclampsia in current pregnancy and control group ( n =111) with physiological pregnancy. All pregnant women in the period from 11 to 14 weeks gestation, blood samples were taken for determination of laboratory parameters (CBC, urea, creatinine, uric acid, C- reactive protein and pregnancy associates plasma protein PAPP-A). Results Pregnant women who developed pre-eclampsia in current pregnancy had significantly higher values of CRP and PAPP-a than in control group, while the values of leukocytes, platelets, red blood cells, urea, creatinin and uric acid were not significantly different between groups. Conclusion The results of this study suggest that in pregnancy with preeclampsia, reactions of maternal endothelium on the placental factors of ischemia starts already in early pregnancy with consequent increase in marker of acute inflammatory reaction (CRP) and PAPP-A, that much earlier precede the manifestation of clinical symptoms of multiorgan dysfunction in preeclampsia.