Abstract
Magnesium sulphate (MS), causes bronchodilation by inhibiting bronchial smooth muscle contraction, interferes with parasympathetic stimulation, and prevents acetylcholine release to axon terminals [1]. It reduces inflammation by inhibiting mast cell degranulation and reduces thromboxane, histamine and leukotrienes [2]. Some pediatric studies suggest that MS, b-2-agonists and steroids are beneficial in acute moderate/severe asthma by reducing hospitalization and absolute risk [3].
Highlights
Magnesium sulphate (MS), causes bronchodilation by inhibiting bronchial smooth muscle contraction, interferes with parasympathetic stimulation, and prevents acetylcholine release to axon terminals [1]
Some pediatric studies suggest that MS, b-2-agonists and steroids are beneficial in acute moderate/severe asthma by reducing hospitalization and absolute risk [3]
Case Report A 5-year-old boy with past asthma presented with rapidly progressing asthma unrelieved by prednisolone and multiple doses of salbutamol, ipratropium bromide
Summary
Magnesium sulphate (MS), causes bronchodilation by inhibiting bronchial smooth muscle contraction, interferes with parasympathetic stimulation, and prevents acetylcholine release to axon terminals [1]. Some pediatric studies suggest that MS, b-2-agonists and steroids are beneficial in acute moderate/severe asthma by reducing hospitalization and absolute risk [3]
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