Abstract
The central mechanism of inducing fever is triggered by an action of prostaglandin (PG) E2 on neurons in the preoptic area (POA) mostly through the EP3 subtype of PGE receptor. EP3 receptor-expressing POA neurons directly project to the dorsomedial hypothalamus (DMH) and the rostral raphe pallidus nucleus (rRPa), both of which are key sites for the control of thermoregulatory effectors. Major sympathetic effector responses contributing to fever development in rodents are thermogenesis in brown adipose tissue (BAT) and heat conservation through skin vasoconstriction.
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