P8.132: Living Kidney-Donation: Is the Donator Sheltered From Cardiovascular Risk Factors?

Abstract

Introduction: Living kidney transplantation represents the best therapeutic option for end-stage kidney disease patients. However, a multitude of questions has arisen regarding the risks encountered by the donor following kidney donation, namely cardiovascular risk factors such as diabetes and hypertension. Methods: Herein is a monocentric, retrospective, descriptive and analytical study reporting data relative to blood pressure and glycemic equilibrium among 40 living kidney-donors that were admitted in our department of nephrology and kidney transplantation with the purpose of donating and were followed-up in our consultation. Clinical and biological data were collected before the donation and during every visit thereafter. Results: Median follow-up was 9 years. The median age was 42 years.75% were female.62% were married.80% of donors were related to the recipient. One donor had a history of hypertension well-controlled on monotherapy. Pre donation work up showed: the median systolic and diastolic blood pressures at baseline were 112,5 and 70 mmHg respectively and that of glycemia was 4,88mmol/l. The median time of hospitalization was 5 days. During follow-up, and comparatively, with pre-donation assessment, systolic and diastolic blood pressures were relatively stable with significantly higher blood pressure at long term only (p=0,03 for each). Two patients developed hypertension after donation and both were well-controlled on monotherapy. The median of glycemia has shown a progressive increase during the study period of 5 years with a significant difference at short and long term only (p-value of 0,02 and 0,006 respectively). One donor has developed diabetes that was well-controlled on metformin. One female donor had 2 pregnancies without gestational diabetes no hypertension or preeclampsia. No death was observed and no cardiovascular events were encountered. Conclusion: Our results show that living kidney donation can be safely performed provided that a meticulous evaluation of the donors is ensured prior to nephrectomy. Moreover, a regular follow-up is paramount allowing an early screening for complications and a prompt initiation of treatment.