Abstract
Dehydroepiandrosterone (DHEA) is a steroid primarily derived from the adrenal. The hormone circulates in high amounts mainly during female reproductive life; however, concentrations fall progressively with age. Recently, some studies have speculated that exogenous replacement of DHEA in the elderly and poor responders patients may contribute to elevate the ovarian recruitment by increasing serum IGF-I concentrations and/or in others growth factors acting directly in ovarian folliculogenesis. In this pilot study we have aimed to test the efficiency of oral DHEA intake in combination with gonadotrophin stimulation to enhance ovarian response, in poor responder patients.
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