P771 Predictors of health-related quality of life in patients with moderate to severely active ulcerative colitis receiving biological therapy

Abstract

Patients with ulcerative colitis have reduced health-related quality of life compared with the general population. Current treatment strategy aims to reduce patients’ symptoms and increase health-related quality of life. We aimed to investigate which symptoms of ulcerative colitis, correlate to decreased health-related quality of life. Among 744 patients with moderate to severely active ulcerative colitis receiving biological therapy in a cross-sectional national study, we determined which disease-related symptoms, measured with Simple Clinical Colitis Activity Index, worsened health-related quality of life scores across the four Short Health Scale dimensions, while adjusting for treatment, age and clinical manifestation and stratifying for sex. Overall disease activity was associated with worsening of health-related quality of life. Both sexes had decreased health-related quality of life in all dimensions for the symptoms: bowel frequency during daytime, urgency of defaecation and blood in stool. Women were more often negatively affected by bowel frequency during night-time and arthritis than men, and being a woman was a significant predictor of worse health-related quality of life in some dimensions. Decreased health-related quality of life was most prominently associated to bowel frequency during daytime, urgency of defaecation and blood in stool. Other symptoms such as bowel frequency during night-time and arthritis were associated for some health-related quality of life dimensions, and appear to vary between the sexes. Furthermore, female sex was an independent predictor of worse health-related quality of life for some domains.