Abstract
Leptomeningeal disease in metastatic non-small cell lung cancer remains a challenging condition with guarded prognosis. Although several EGFR TKI (in particular osimertinib) have been reported to have good intra-cranial activity, however this has not been reported for dacomitinib as yet. Of note, brain metastases patients were excluded from the dacomitinib registration trial ARCHER 1050. This is in spite of the fact that pre-clinical data shows good levels of dacomitinib in the brain in mice-models.
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