Abstract
P75 neurotrophin receptor activates epidermal stem cell differentiation via ERK, JNK and AKT pathways
Highlights
Skin serves as a protective organ for mammals, which prevents pathogens, radiation etc [1, 2]
We found that p75 neurotrophin receptor (p75NTR) expression was markedly increased in p75NTRvo epidermal stem cells (ESCs) compared with that in empty vector (EV) ESCs (Figure 1A). (*p < 0.05)
We examined the expression of stem cell biomakers following p75NTRvo ESCs construction
Summary
Skin serves as a protective organ for mammals, which prevents pathogens, radiation etc [1, 2]. It is reported that epidermal stem cells are responsible for maintaining skin homeostasis [5]. The mechanisms of the differentiation of epidermal stem cells were not clear. P75NTR serves as a low-affnity receptor to mediate diverse functions [9]. It is reported that p75NTR interacts with a variety of proteins [12] that in turn induce different pathways [13]. This interaction allows p75NTR to play an important role in the regulation of some processes, such as proliferation, migration and differentiation [14]. The potential signaling pathways that p75NTR participated in ESCs remain unknown
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