Abstract
Meeting abstracts Engineering the antigen receptor gene in patients' lymphocytes is one promising strategy to create antigen-specific lymphocytes without senescent phenotypes. The strategy provides an opportunity to extend the application of adoptive T cell therapy for cancer patients. However,
Highlights
Engineering the antigen receptor gene in patients’ lymphocytes is one promising strategy to create antigen-specific lymphocytes without senescent phenotypes
The strategy provides an opportunity to extend the application of adoptive T cell therapy for cancer patients
Materials and methods MAGE-A4-specific TCR a and b chains were cloned from a human T cell clone that recognises MAGEA4143-151 peptide in a HLA-A*24:02 restricted manner
Summary
Adoptive transfer of TCR gene-transduced lymphocytes targeting MAGE-A4 for refractory esophageal cancer. H Shiku1*, H Ikeda, Y Miyahara, M Ishihara, N Katayama, D Tomura, I Nukaya, J Mineno, K Takesako, S Kageyama. From 1st Immunotherapy of Cancer Conference (ITOC1) Munich, Germany. From 1st Immunotherapy of Cancer Conference (ITOC1) Munich, Germany. 12-14 March 2014
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