P70.10 Prevalence of KRAS and Concomitant Mutations in Advanced Lung Adenocarcinoma Patients

Abstract

One of the most frequently mutated oncogenes in cancer belongs to the Ras family of proto-oncogenes and encodes distinct key signalling events. RAS gain-of-function mutations are present in ∼30% of all human cancers, where KRAS is the most frequent mutated isoform being altered in different cancer types including lung cancer. This study aims to analyse, retrospectively, the incidence of KRAS mutations, with emphasis in the evaluation of G12C mutations and the presence of KRAS concomitant mutations.