P70.05 Identification of Germline Mutations in Young Never Smokers With Lung Adenocarcinoma by Whole Exome Sequencing

Abstract

Recently, an increasing number of young never-smokers were diagnosed with lung cancer. Although environmental risk factors such as second-hand smoke, radon, and indoor air pollutants might cause never-smoking lung cancer, a large proportion of these patients do not have a definite association with established environmental risk factors. The aim of this study was to investigate the genetic predisposition of lung cancer in these patients and discover candidate pathogenic variants for lung adenocarcinoma in young never-smokers.