P70 Photoallergical contact dermatitis from diclophenac: cross reaction to aceclophenac

Abstract

Introduction: Cutaneous adverse reactions from topical or systemic administration of non‐steroidal anti‐inflammatory drugs (NSAID) are frequently described. New cases of adverse reactions from NSAIDs are reported, but the most frequently involved are drugs as ketoprofen or piroxicam. We report a case of photoallergical contact dermatitis from diclophenac with possible cross reaction to aceclophenac.Material and methods: A 63‐year‐old‐man, allergic to penicillin, developed eczematous lesions on hands and face, after applying a medicament containing diclophenac. Patch test and photopatch test (5 J/cm2) were performed with a photoallergen battery (Chemotechnique diagnosticsÒ), a NSAIDs battery (Aristegui lab.Ò) and aceclophenac 1%, 5% and 10% in pet. Readings were done at 48 and 96 hours in epicutaneous test and at 24 and 72 hours in photoallergic study, following the ICDRG criteria.Results: The results of photoallergic study were as follows: diclophenac 1%, 5% and 10% in pet. and aceclophenac 10% in pet. positive at 24 and 72 hours. The remaining compounds of the NSAIDs battery were negative.Conclusions: Diclophenac is a NAIDs derived from aryl alcanoic acid group used both topically and systemically in Spain. Some adverse reactions have been reported as exanthema, urticaria, eczema or Steven‐Johnson’s syndrome. We have found only two cases reported as photosensitization from diclophenac. In one of them, the clinical lesion was described as a granuloma annular‐like and photoallergic study was negative. We report a photocontact dermatitis from diclophenac with positive photopatch test. Photopatch test positive to aceclophenac may be explained as a cross reaction among group.