Abstract
Chronic intermittent hypoxia (CIH) yields persistent elevations in sympathetic nerve activity (SNA) and arterial pressure (AP). In addition, chemoreflex activation by acute hypoxia or cyanide evokes a larger rise in SNA in rats after CIH due to enhanced sensory and central mechanisms. We examined the hypothesis that other sympatho-excitatory reflexes are also augmented after CIH. Male Sprague–Dawley rats (4 wks old) were exposed to CIH (6% O2 for 40 s, every 9 min, 8 h/day, 2 wks). Isoflurane-anesthetized, ventilated, paralyzed rats were prepared for recording AP, splanchnic SNA, phrenic nerve discharge and then switched urethane anesthesia (1.5 g/kg, iv).
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